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python - Pandas won't fillna() inplace

I'm trying to fill NAs with "" on 4 specific columns in a data frame that are string/object types. I can assign these columns to a new variable as I fillna(), but when I fillna() inplace the underlying data doesn't change.

a_n6 = a_n6[["PROV LAST", "PROV FIRST", "PROV MID", "SPEC NM"]].fillna("")
a_n6

gives me:

<class 'pandas.core.frame.DataFrame'>
Int64Index: 1542 entries, 0 to 3611
Data columns (total 4 columns):
PROV LAST     1542  non-null values
PROV FIRST    1542  non-null values
PROV MID      1542  non-null values
SPEC NM       1542  non-null values
dtypes: object(4)

but

a_n6[["PROV LAST", "PROV FIRST", "PROV MID", "SPEC NM"]].fillna("", inplace=True)
a_n6

gives me:

<class 'pandas.core.frame.DataFrame'>
Int64Index: 1542 entries, 0 to 3611
Data columns (total 7 columns):
NPI           1103  non-null values
PIN           1542  non-null values
PROV FIRST    1541  non-null values
PROV LAST     1542  non-null values
PROV MID      1316  non-null values
SPEC NM       1541  non-null values
flag          439  non-null values
dtypes: float64(2), int64(1), object(4)

It's just one row, but still frustrating. What am I doing wrong?

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Use a dict as the value argument to fillna()

As mentioned in the comment by @rhkarls on @Jeff's answer, using .loc indexed to a list of columns won't support inplace operations, which I too find frustrating. Here's a workaround.

Example:

import pandas as pd
import numpy as np

df = pd.DataFrame({'a':[1,2,3,4,np.nan],
                   'b':[6,7,8,np.nan,np.nan],
                   'x':[11,12,13,np.nan,np.nan],
                   'y':[16,np.nan,np.nan,19,np.nan]})
print(df)
#     a    b     x     y
#0  1.0  6.0  11.0  16.0
#1  2.0  7.0  12.0   NaN
#2  3.0  8.0  13.0   NaN
#3  4.0  NaN   NaN  19.0
#4  NaN  NaN   NaN   NaN

Let's say we want to fillna for x and y only, not a and b.

I would expect using .loc to work (as in an assignment), but it doesn't, as mentioned earlier:

# doesn't work
df.loc[:,['x','y']].fillna(0, inplace=True)
print(df) # nothing changed

However, the documentation says that the value argument to fillna() can be:

alternately a dict/Series/DataFrame of values specifying which value to use for each index (for a Series) or column (for a DataFrame). (values not in the dict/Series/DataFrame will not be filled).

It turns out that using a dict of values will work:

# works
df.fillna({'x':0, 'y':0}, inplace=True)
print(df)
#     a    b     x     y
#0  1.0  6.0  11.0  16.0
#1  2.0  7.0  12.0   0.0
#2  3.0  8.0  13.0   0.0
#3  4.0  NaN   0.0  19.0
#4  NaN  NaN   0.0   0.0

Also, if you have a lot of columns in your subset, you could use a dict comprehension, as in:

df.fillna({x:0 for x in ['x','y']}, inplace=True) # also works

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