FTP-SSL Explicit is well supported by native Python. After setting up the connection, you can use all the standard ftplib commands. More can be found at:
http://docs.python.org/2/library/ftplib.html#ftplib.FTP_TLS
Here's a basic example for downloading a file:
from ftplib import FTP_TLS
ftps = FTP_TLS('ftp.MySite.com')
ftps.login('testuser', 'testpass') # login anonymously before securing control channel
ftps.prot_p() # switch to secure data connection.. IMPORTANT! Otherwise, only the user and password is encrypted and not all the file data.
ftps.retrlines('LIST')
filename = 'remote_filename.bin'
print 'Opening local file ' + filename
myfile = open(filename, 'wb')
ftps.retrbinary('RETR %s' % filename, myfile.write)
ftps.close()
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