Almost every Chrome flag can be set via the command line. Here is a quite exhaustive list of command line parameters, but also keep in mind that there would be even more in newer versions!
So basically you would launch chrome with these command line flags already set. That's the best way to go about it.
You cannot manually set this using Javascript or other behavior. The only way you can set this programmatically (other than command line flags) is to use Capybara (a tool that can open and control browsers, generally used for running automated tests), open Chrome and then manually navigate to "chrome://flags" and click the necessary combo boxes.
EDIT: Watir is also as good as Capybara
Watir is another browser automation framework (similar to Capybara) but is much easier to setup and start with. Here are examples on how you would open a web page and select a combo box, and here are instructions on using it with Chrome. You can write a single ruby file which looks like:
require 'watir-webdriver'
browser = Watir::Browser.new :chrome
browser.goto "chrome://flags"
browser.select_list(:id => <combo box id>).select("Enabled")
...
Persisting the Flags when using WebDriver
Chrome has the --user-data-dir
switch which is where all the profile settings are saved. The default directories that Chrome uses (on Windows/Mac/Linux) [is documented here. Generally, WebDriver launches with a temporary --user-data-dir
, and later deletes the temporary folder after use. So whatever flags you set will be lost when you run Chrome again! So set --user-data-dir
to your user's default profile directory, and then whatever flags you set will be persisted.
Edit 2: Added comprehensive list of chrome command line flags
Edit 3: Added instructions for persisting the flags in Webdriver
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