You receive two keydown events: The first is for the control key, and the second is for the letter with the modifier flag turned on. Here's how you listen for a key with a modifier pressed:
document.addEventListener("keydown", function(e) {
if (e.keyCode == 83 && (navigator.platform.match("Mac") ? e.metaKey : e.ctrlKey)) {
e.preventDefault();
// Process event...
}
}, false);
Taking a page from Google Docs, it uses Cmd-S on Mac and Ctrl-S on other platforms.
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