You can't do that, but you can create a copy of the table with only the columns you want :
DataView view = new DataView(table);
DataTable table2 = view.ToTable(false, "FirstColumn", "SecondColumn", "ThirdColumn");
Optionally you can return rows that have distinct values for the selected columns :
DataView view = new DataView(table);
DataTable table2 = view.ToTable(true, "FirstColumn", "SecondColumn", "ThirdColumn");
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