You can move the node.exe to the d drive. Then check your environment path. Type set in a command window or in computer properties. Make sure you have the folder that contains node.exe in your path. Running node in a command window will work from any folder then.
For installed npm packages, ie.. node_modules folder.. That just needs to be in a directory above where your writing your code, so try putting that folder in d: Assuming your going to be writing your apps on the d drive now.
In .npmrc file, change prefix setting to desired folder. Global packages get installed in node_modules under that folder
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