This should still be possible with VS2010 by editing the csproj aka msbuild file.
Taken from this thread on CodePlex.
<ItemGroup>
<JavaScriptFiles Remove="@(JavaScriptFiles)" />
<JavaScriptFiles Include="../js/2.js"/>
</ItemGroup>
<CompressorTask
JavaScriptFiles="@(JavaScriptFiles)"
ObfuscateJavaScript="True"
PreserveAllSemicolons="False"
DisableOptimizations="Nope"
EncodingType="Default"
DeleteJavaScriptFiles="false"
LineBreakPosition="-1"
JavaScriptOutputFile="../js/2.min.js"
LoggingType="ALittleBit"
ThreadCulture="en-au"
IsEvalIgnored="false"/>
<ItemGroup>
<JavaScriptFiles Remove="@(JavaScriptFiles)" />
<JavaScriptFiles Include="../js/3.js" />
<JavaScriptFiles Include="../js/4.js" />
</ItemGroup>
<CompressorTask
CssFiles="@(CssFiles)"
DeleteCssFiles="false"
CssOutputFile="../css/release.css"
CssCompressionType="YuiStockCompression"
JavaScriptFiles="@(JavaScriptFiles)"
ObfuscateJavaScript="True"
PreserveAllSemicolons="False"
DisableOptimizations="Nope"
EncodingType="Default"
DeleteJavaScriptFiles="false"
LineBreakPosition="-1"
JavaScriptOutputFile="../js/3.min.js"
LoggingType="ALittleBit"
ThreadCulture="en-au"
IsEvalIgnored="false"/>
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…