you may want to look at pandas.resample:
df['Data'].resample('5Min', how='mean')
or, as how = 'mean'
is default parameter:
df['Data'].resample('5Min')
For example:
>>> rng = pd.date_range('1/1/2012', periods=10, freq='Min')
>>> df = pd.DataFrame({'Data':np.random.randint(0, 500, len(rng))}, index=rng)
>>> df
Data
2012-01-01 00:00:00 488
2012-01-01 00:01:00 172
2012-01-01 00:02:00 276
2012-01-01 00:03:00 5
2012-01-01 00:04:00 233
2012-01-01 00:05:00 266
2012-01-01 00:06:00 103
2012-01-01 00:07:00 40
2012-01-01 00:08:00 274
2012-01-01 00:09:00 494
>>>
>>> df['Data'].resample('5Min')
2012-01-01 00:00:00 234.8
2012-01-01 00:05:00 235.4
You can find more examples here.
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