To do it entirely in PL/SQL, the file would need to be on the server, located in a directory which you'd need to define in the database. Create the following objects:
CREATE OR REPLACE DIRECTORY
BLOB_DIR
AS
'/oracle/base/lobs'
/
CREATE OR REPLACE PROCEDURE BLOB_LOAD
AS
lBlob BLOB;
lFile BFILE := BFILENAME('BLOB_DIR', 'filename');
BEGIN
INSERT INTO table (id, your_blob)
VALUES (xxx, empty_blob())
RETURNING your_blob INTO lBlob;
DBMS_LOB.OPEN(lFile, DBMS_LOB.LOB_READONLY);
DBMS_LOB.OPEN(lBlob, DBMS_LOB.LOB_READWRITE);
DBMS_LOB.LOADFROMFILE(DEST_LOB => lBlob,
SRC_LOB => lFile,
AMOUNT => DBMS_LOB.GETLENGTH(lFile));
DBMS_LOB.CLOSE(lFile);
DBMS_LOB.CLOSE(lBlob);
COMMIT;
END;
/
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