Short answer: No.
Longer answer: As far as I am aware tere is no way to integrate C-libraries with IronPython in the default python way. Since pandas / numpy use a heavy dose of c code, that is a showstopper.
We use Python.net for this task - basically we embed an python interpreter in .NET and retrieve the results of our computations. That works well and avoids the problems which arise due to IronPython. Furthermore, the "hosted" python process is 100% native, so no library problems should arise.
There can be some problems with subprocesses, since the process is a daemon, but they can be circumvented.
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