I believe no, since there is no difference in compiled IL.
var x = null as object;
var x1 = (object)null;
object x2 = null;
gets compiled to
IL_0001: ldnull
IL_0002: stloc.0 // x
IL_0003: ldnull
IL_0004: stloc.1 // x1
IL_0005: ldnull
IL_0006: stloc.2 // x2
You can see all the locals are initialized to null using ldnull
opcode only, so there is no difference.
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