Few months has passed since I originally posted the question and I made it through!
As @Brett DeWoody correctly noted the right approach is to be strictly related to the number od DOM elements on the screen (I'm referring mainly to markers). The more the merrier if you device is faster (CPU especially). Since the app I was developing has both desktop and tablet as target devices, CPU was a relevant factor just like the marker-density of different geo-areas.
I decided to separate DBase querying/fetching and map representation/displaying. Basically the user adjusts controls/inputs to filter the whole dataset, afterwards records are fetched and Leaflet.markercluster does the job of representation. When a filter is modified the cycle starts over. User can choose the map zoom level of clusterization depending on their CPU power.
In my particular scenario the above mentioned represented the best approach (verified by console.time). I found that viewport optimisation was good for lower marker-density areas (a pity).
Hope it may be helpful.
Cheers,
Luca
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…