Package tldextract makes this task very easy, and then you can use urlparse as suggested if you need any further information:
>> import tldextract
>> tldextract.extract("http://lol1.domain.com:8888/some/page"
ExtractResult(subdomain='lol1', domain='domain', suffix='com')
>> tldextract.extract("http://sub.lol1.domain.com:8888/some/page"
ExtractResult(subdomain='sub.lol1', domain='domain', suffix='com')
>> urlparse.urlparse("http://sub.lol1.domain.com:8888/some/page")
ParseResult(scheme='http', netloc='sub.lol1.domain.com:8888', path='/some/page', params='', query='', fragment='')
Note that tldextract properly handles sub-domains.
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