I use JSPM to make my angular2 projects production ready. Other popular tools like JSPM include webpack, and browserfy. One of the important tasks that JSPM will accomplish is to bundle the various modules that make up your angular2 project. I also set the "selfExecutingBundle" flag to true and have JSPM make one bundled js file (e.g. myApp.bundled.js) and from there I minify it (myApp.bundled.min.js) and this one script reference is used in the index.html file.
<html>
<head>
<title>Hello Angular World</title>
</head>
<body>
<div>
<my-app>Loading...</my-app>
</div>
<script src="/js/myApp.bundle.min.js"></script>
</body>
</html>
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