If you want to convert a python datetime to seconds since epoch you could do it explicitly:
>>> (datetime.datetime(2012,04,01,0,0) - datetime.datetime(1970,1,1)).total_seconds()
1333238400.0
In Python 3.3+ you can use timestamp()
instead:
>>> datetime.datetime(2012,4,1,0,0).timestamp()
1333234800.0
Why you should not use datetime.strftime('%s')
Python doesn't actually support %s as an argument to strftime (if you check at http://docs.python.org/library/datetime.html#strftime-and-strptime-behavior it's not in the list), the only reason it's working is because Python is passing the information to your system's strftime, which uses your local timezone.
>>> datetime.datetime(2012,04,01,0,0).strftime('%s')
'1333234800'
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…