These are usually to make sure that the browser gets a new version when the site gets updated with a new version, e.g. as part of our build process we'd have something like this:
/Resources/Combined.css?v=x.x.x.buildnumber
Since this changes with every new code push, the client's forced to grab a new version, just because of the querystring. Look at this page (at the time of this answer) for example:
<link ... href="http://sstatic.net/stackoverflow/all.css?v=c298c7f8233d">
I think instead of a revision number the SO team went with a file hash, which is an even better approach, even with a new release, the browsers only forced to grab a new version when the file actually changes.
Both of these approaches allow you to set the cache header to something ridiculously long, say 20 years...yet when it changes, you don't have to worry about that cache header, the browser sees a different querystring and treats it as a different, new file.
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