Tuples are immutable; you can't change which variables they contain after construction. However, you can concatenate or slice them to form new tuples:
a = (1, 2, 3)
b = a + (4, 5, 6) # (1, 2, 3, 4, 5, 6)
c = b[1:] # (2, 3, 4, 5, 6)
And, of course, build them from existing values:
name = "Joe"
age = 40
location = "New York"
joe = (name, age, location)
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