For mixed position and index, use .ix
. BUT you need to make sure that your index is not of integer, otherwise it will cause confusions.
df.ix[0, 'COL_NAME'] = x
Update:
Alternatively, try
df.iloc[0, df.columns.get_loc('COL_NAME')] = x
Example:
import pandas as pd
import numpy as np
# your data
# ========================
np.random.seed(0)
df = pd.DataFrame(np.random.randn(10, 2), columns=['col1', 'col2'], index=np.random.randint(1,100,10)).sort_index()
print(df)
col1 col2
10 1.7641 0.4002
24 0.1440 1.4543
29 0.3131 -0.8541
32 0.9501 -0.1514
33 1.8676 -0.9773
36 0.7610 0.1217
56 1.4941 -0.2052
58 0.9787 2.2409
75 -0.1032 0.4106
76 0.4439 0.3337
# .iloc with get_loc
# ===================================
df.iloc[0, df.columns.get_loc('col2')] = 100
df
col1 col2
10 1.7641 100.0000
24 0.1440 1.4543
29 0.3131 -0.8541
32 0.9501 -0.1514
33 1.8676 -0.9773
36 0.7610 0.1217
56 1.4941 -0.2052
58 0.9787 2.2409
75 -0.1032 0.4106
76 0.4439 0.3337
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