You cannot do it with just a single MySQL command, however you can use MySQL to construct the statement for you:
In the MySQL shell or through PHPMyAdmin, use the following query
SELECT CONCAT( 'DROP TABLE ', GROUP_CONCAT(table_name) , ';' )
AS statement FROM information_schema.tables
WHERE table_name LIKE 'myprefix_%';
This will generate a DROP statement which you can than copy and execute to drop the tables.
EDIT: A disclaimer here - the statement generated above will drop all tables in all databases with that prefix. If you want to limit it to a specific database, modify the query to look like this and replace database_name with your own database_name:
SELECT CONCAT( 'DROP TABLE ', GROUP_CONCAT(table_name) , ';' )
AS statement FROM information_schema.tables
WHERE table_schema = 'database_name' AND table_name LIKE 'myprefix_%';
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