You can use the Triggers property of the UpdatePanel to register actions that trigger a full postback.
Add a PostBackTrigger object to that property, containig the ControlID of the control which needs to trigger a full postback.
<asp:UpdatePanel ID="UpdatePanel1" UpdateMode="Conditional" runat="server">
<ContentTemplate>
...
</ContentTemplate>
<Triggers>
<asp:PostBackTrigger ControlID="myFullPostBackControlID" />
</Triggers>
</asp:UpdatePanel>
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