>>> a=[1,2,3,4,5,7,8,9,10]
>>> sum(xrange(a[0],a[-1]+1)) - sum(a)
6
alternatively (using the sum of AP series formula)
>>> a[-1]*(a[-1] + a[0]) / 2 - sum(a)
6
For generic cases when multiple numbers may be missing, you can formulate an O(n) approach.
>>> a=[1,2,3,4,7,8,10]
>>> from itertools import imap, chain
>>> from operator import sub
>>> print list(chain.from_iterable((a[i] + d for d in xrange(1, diff))
for i, diff in enumerate(imap(sub, a[1:], a))
if diff > 1))
[5, 6, 9]
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