Please explain what are the main differences and when should I use what. The focus on web multi-threaded applications.
lock allows only one thread to execute the code at the same time. ReaderWriterLock may allow multiple threads to read at the same time or have exclusive access for writing, so it might be more efficient. If you are using .NET 3.5 ReaderWriterLockSlim is even faster. So if your shared resource is being read more often than being written, use ReaderWriterLockSlim. A good example for using it is a file that you read very often (on each request) and you update the contents of the file rarely. So when you read from the file you enter a read lock so that many requests can open it for reading and when you decide to write you enter a write lock. Using a lock on the file will basically mean that you can serve one request at a time.
ReaderWriterLockSlim
lock
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