You use whatever you have the information for.
If you have an instance and a static type you want to check against, use is
.
If you don't have the static type, you just have a Type
object, but you have an instance you want to check, use IsInstanceOfType
.
If you don't have an instance and you just want to check the compatibility between a theoretical instance of a Type
and another Type
, use IsAssignableFrom
.
But really is seems like you are just re-implementing the as operator (except that yours would also work for non-nullable value types, which is usually not a big limitation).
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