Unfortunately, the September 30, 2011 blog post is worded in a misleading way. The relevant section is "Support for Multiple Domains in the Developer App." Reading that paragraph, it would appear that there are no restrictions in terms of which domains can be lumped together under one application.
However, when I tried adding a second domain to an existing application, I received an error message saying that the new domain must be derived from the Site URL. One comment on that blog post described a similar experience. And that restriction was confirmed by a reply to that comment by someone in Developer Relations at Facebook, explaining that "All app domains must be derived from the site URL."
I believe the confusion arises from incorrect wording in the post itself, which says "Your App’s URL (Website and/or Mobile Web URL) must be derived from one of the domains listed in the App Domain field."
*Update: Just to clarify what types of domains are allowed, let's say your Site URL is "mywebsite.com". You would be allowed to add "mywebsite.co.uk" as an additional App Domain, but you would not be allowed to add "myalternatewebsite.com".
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