MySQL 5.x can do this via the INFORMATION_SCHEMA database. This database contains information about tables, views, columns, etc.
SELECT *
FROM `INFORMATION_SCHEMA`.`TABLES`
WHERE
DATE_SUB(NOW(), INTERVAL 1 HOUR) < `UPDATE_TIME`
Returns all tables that have been updated (UPDATE_TIME) in the last hour. You can also filter by database name (TABLE_SCHEMA column).
An example query:
SELECT
CONCAT(`TABLE_SCHEMA`, '.', `TABLE_NAME`) AS `Table`,
UPDATE_TIME AS `Updated`
FROM `INFORMATION_SCHEMA`.`TABLES`
WHERE
DATE_SUB(NOW(), INTERVAL 3 DAY) < `UPDATE_TIME`
AND `TABLE_SCHEMA` != 'INFORMATION_SCHEMA'
AND `TABLE_TYPE` = 'BASE TABLE';
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