I have tried this for smaller array, so test it with yours:
import numpy as np
nbig = 100
nsmall = 20
big = np.arange(nbig * nbig).reshape([nbig, nbig]) # 100x100
small = big.reshape([nsmall, nbig//nsmall, nsmall, nbig//nsmall]).mean(3).mean(1)
An example with 6x6 -> 3x3:
nbig = 6
nsmall = 3
big = np.arange(36).reshape([6,6])
array([[ 0, 1, 2, 3, 4, 5],
[ 6, 7, 8, 9, 10, 11],
[12, 13, 14, 15, 16, 17],
[18, 19, 20, 21, 22, 23],
[24, 25, 26, 27, 28, 29],
[30, 31, 32, 33, 34, 35]])
small = big.reshape([nsmall, nbig//nsmall, nsmall, nbig//nsmall]).mean(3).mean(1)
array([[ 3.5, 5.5, 7.5],
[ 15.5, 17.5, 19.5],
[ 27.5, 29.5, 31.5]])