No. Anonymous boxes cannot be directly targeted for CSS styling. CSS styles need a "hook" in the HTML to attach to. That hook is an HTML tag. Without the tag, CSS has nothing to target. This concept applies across box models, including flex and block formatting contexts.
More about anonymous boxes:
From the CSS spec:
9.2.2.1 Anonymous inline
boxes
Any text that is directly contained inside a block container element
must be treated as an anonymous inline element.
The flexbox specification provides for similar behavior.
4. Flex Items
Each in-flow child of a flex container becomes a flex item, and each
contiguous run of text that is directly contained inside a flex
container is wrapped in an anonymous flex item.
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