This is one of my biggest frustrations with Matplotlib. I often work with raster data where for example i want to add a colormap, legend and some title. Any simple example from the matplotlib gallery doing so will result in a different resolution and therefore resampled data. Especially when doing image analysis you dont want any (unwanted) resampling.
Here is what i usually do, although i would love to know if there are simpler or better ways.
Lets start with loading a picture and outputting it just as it is with the same resolution:
import matplotlib.pyplot as plt
import urllib2
# load the image
img = plt.imread(urllib2.urlopen('http://upload.wikimedia.org/wikipedia/en/thumb/5/56/Matplotlib_logo.svg/500px-Matplotlib_logo.svg.png'))
# get the dimensions
ypixels, xpixels, bands = img.shape
# get the size in inches
dpi = 72.
xinch = xpixels / dpi
yinch = ypixels / dpi
# plot and save in the same size as the original
fig = plt.figure(figsize=(xinch,yinch))
ax = plt.axes([0., 0., 1., 1.], frameon=False, xticks=[],yticks=[])
ax.imshow(img, interpolation='none')
plt.savefig('D:\mpl_logo.png', dpi=dpi, transparent=True)
Note that i manually defined the axes position so that spans the entire figure.
In a similar way as above you could add some margin around the image to allow for labels or colorbars etc.
This example adds a 20% margin above the image, which is then used for plotting a title:
fig = plt.figure(figsize=(xinch,yinch/.8))
ax = plt.axes([0., 0., 1., .8], frameon=False, xticks=[],yticks=[])
ax.imshow(img, interpolation='none')
ax.set_title('Matplotlib is fun!', size=16, weight='bold')
plt.savefig('D:\mpl_logo_with_title.png', dpi=dpi)
So the figure y-size (height) is increased and the y-size of the axes is decreased equally. This gives a larger (overall) output image, but the axes area will still be the same size.
It might be nice the have a figure or axes property like .set_scale() to force a true 1-on-x output.