The bold property of the font itself is read only, but the actual font property of the text box is not. You can change the font of the textbox to bold as follows:
textBox1.Font = new Font(textBox1.Font, FontStyle.Bold);
And then back again:
textBox1.Font = new Font(textBox1.Font, FontStyle.Regular);
与恶龙缠斗过久,自身亦成为恶龙;凝视深渊过久,深渊将回以凝视…