While the Popen
answers are reasonable for the general case, I would recommend win32api
for this specific case, if you want to do something useful with it:
It goes something like this:
from win32com.client import Dispatch
xl = Dispatch('Excel.Application')
wb = xl.Workbooks.Open('C:\Documents and Settings\GradeBook.xls')
xl.Visible = True # optional: if you want to see the spreadsheet
Taken from a mailing list post but there are plenty of examples around.
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