Personally, I'd rarely bother with sparse for an array that is only 25% non-zeros. If you don't believe me, try it yourself.
A = sprand(2000,2000,0.25);
tic,B = A*A;toc
Elapsed time is 1.771668 seconds.
Af = full(A);
tic,B = Af*Af;toc
Elapsed time is 0.499045 seconds.
The extra work involved with this as a sparse matrix costs too much to be worth the bother. Now try it with a really sparse matrix.
A = sprand(2000,2000,0.005);
Af = full(A);
tic,B = A*A;toc
Elapsed time is 0.037763 seconds.
tic,B = Af*Af;toc
Elapsed time is 0.446680 seconds.
Of course, your own problem will be different, but it will not be that different. Sparse matrices are a true boon for the person who uses truly sparse matrices, but 25% non-zeros is simply not "sparse" enough for any gain in most cases.
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