Depends on Storage Engine
MyISAM (Caches Index Pages From .MYI files)
SELECT FLOOR(SUM(index_length)/POWER(1024,2)) IndexSizesMB
FROM information_schema.tables WHERE engine='MyISAM' AND
table_schema NOT IN ('information_schema','performance_schema','mysql');
Subtract that from key_buffer_size
. If the answer > 0, then Yes
InnoDB (Caches Data and Index Pages)
SELECT FLOOR(SUM(data_length+index_length)/POWER(1024,2)) InnoDBSizeMB
FROM information_schema.tables WHERE engine='InnoDB';
Subtract that from innodb_buffer_pool_size
. If the answer > 0, then Yes
I wrote about this in the DBA StackExchange
On a dedicated DB Server, make sure InnoDBSizeMB+IndexSizesMB
does not exceed 75% of RAM.
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