I'd say you will probably want to do it using the sp_addextendedproperty stored proc.
Microsoft has some good documentation on it.
Try this:
EXEC sp_addextendedproperty
@name = N'MS_Description', @value = 'Hey, here is my description!',
@level0type = N'Schema', @level0name = 'yourschema',
@level1type = N'Table', @level1name = 'YourTable',
@level2type = N'Column', @level2name = 'yourColumn';
GO
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