Consider interpolate
(Series - DataFrame). This example shows how to fill gaps of any size with a straight line:
df = pd.DataFrame({'date': pd.date_range(start='2013-01-01', periods=10, freq='H'), 'value': range(10)})
df.loc[2:3, 'value'] = np.nan
df.loc[6, 'value'] = np.nan
df
date value
0 2013-01-01 00:00:00 0.0
1 2013-01-01 01:00:00 1.0
2 2013-01-01 02:00:00 NaN
3 2013-01-01 03:00:00 NaN
4 2013-01-01 04:00:00 4.0
5 2013-01-01 05:00:00 5.0
6 2013-01-01 06:00:00 NaN
7 2013-01-01 07:00:00 7.0
8 2013-01-01 08:00:00 8.0
9 2013-01-01 09:00:00 9.0
df['value'].interpolate(method='linear', inplace=True)
date value
0 2013-01-01 00:00:00 0.0
1 2013-01-01 01:00:00 1.0
2 2013-01-01 02:00:00 2.0
3 2013-01-01 03:00:00 3.0
4 2013-01-01 04:00:00 4.0
5 2013-01-01 05:00:00 5.0
6 2013-01-01 06:00:00 6.0
7 2013-01-01 07:00:00 7.0
8 2013-01-01 08:00:00 8.0
9 2013-01-01 09:00:00 9.0
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