Client-side frameworks
In addition to jqGrid, there are several other javascript framework Grids that I've been playing with recently:
Flexigrid: jQuery-based, no
editing features yet, but planned.
Ext's GridPanel: Ext js is
another javascript framework which
interfaces with jQuery.
YUI's DataTable: The Yahoo User
Interface (YUI) is yet another
framework with an editable Grid
control.
These are all client-side components: they operate in the user's browser, disconnected from your server code. Like Tracker1 and several others wrote, you'll have to either write Ajax methods yourself to wire the client-side grid to the server or you can try to take advantage of existing wrappers, such as:
Server-side options
Coolite's Ext wrappers for .NET
One of the in-progress YUI .NET wrapper libraries (YuiDotNet or Yui.NET). I don't think either of these implements a wrapper for the DataTable yet, but they may show you the way to do so.
Connecting the client and the server
If you haven't worked with a lot of Ajax or done much with these javascript frameworks, be prepared for a bit of a learning curve: as you begin to use them, you'll need to constantly bear in mind what's happening on the server and what's happening on the client (and when!).
If you use one of the straight javascript libraries I listed above, as opposed to a .NET wrapper, you'd have to write a server-side method to handle data submission and expose it to the client using your choice of technology (MVC's JsonResult controller actions, establishing WebMethods / ScriptMethods, etc.).
Related Stack Overflow Questions
Using ExtJS in ASP.NET and Returning data from ASP.net to an ExtJS Grid - these are focused on Ext's controls, but the answers contain a lot of good general information about connecting the new generation of javascript framework controls to server applications.
Good Asp.Net excel-like Grid control - you may also be interested in the answers to this question, particularly since it sounds like you want solid editing capabilities.
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