You should avoid reading and writing cell by cell if you can. It is much faster to work with arrays, and read or write entire blocks at once. I wrote a post a while back on reading from worksheets using C#; basically, the same code works the other way around (see below), and will run much faster, especially with larger blocks of data.
var sheet = (Worksheet)Application.ActiveSheet;
var range = sheet.get_Range("A1", "B2");
var data = new string[3,3];
data[0, 0] = "A1";
data[0, 1] = "B1";
data[1, 0] = "A2";
data[1, 1] = "B2";
range.Value2 = data;
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